Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD

Article Abstract:

The genetic transcription and chromatin activity are regulated by molecular entities containing histone deacetylase and ATPase. The mechanism of this regulation is mediated by the corepressor KAP-1 through its plant homeodomain and bromodomain that link Kruppel associated box zinc finger proteins to the NuRD complex.

Protein binding, Domain structure

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Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

Article Abstract:

Research has been conducted on heterochromodomain protein 1 which is required for stable epigenetic gene silencing. The authors report that the recruitment of mammalian heterochromodomain protein 1 to the euchromatic promoter establishes the epigenetically heritable silenced state.

Science & research, Proteins, Gene expression, Drosophila, Mitosis, Cell culture, Tissue culture, Genetic research, Epigenesis, Gene silencing

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Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

Article Abstract:

Analysis of the NuRD subunits, which may give a means for gene silencing by DNA methylation, is discussed. Findings of studying histone deacetylases HDAC1 and HCAC2 and identifying the p70 and p32 subnuntes of NuRD indicate a histone deacetylase core complex.

United Kingdom, Scotland, Histones, Cellular control mechanisms, Cell regulation, Allosteric proteins, Methylation

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