Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis

Article Abstract:

Study is conducted to demonstrate that when in combination with telomerase deficiency, TRF2 acts as a very potent oncogene in vivo. It is shown that telomerase deficiency dramatically accelerates TRF2-induced epithelial carcinogenesis in K5TRF2/[Terc.sup.-/-] mice, coinciding with increased chromosomal instability and DNA damage.

Spain, Genetic aspects, Carcinogenesis, Telomerase, Epithelium

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Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging

Article Abstract:

A "super Ink4a/Arf", mouse strain that carry a modest increase in the activity of the Ink4a/Arf locus is generated. The moddest increases in the activity of Ink4a/Arf tumor suppressor is found to result in a beneficial cancer-resistant phenotype without affecting normal viability or aging.

Phenotype, Phenotypes, Tumor suppressor genes, Tumour suppressor genes

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Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres

Article Abstract:

The mismatch repair (MMR) in response to dysfunctional telomeres was studied. Results highlight a new role of MMR in mediating the cellular response to dysfunctional telomeres.

Telomeres, Fitness (Genetics)

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