Telomere elongation is under the control of the RNAi-based mechanism in the Drosophila germline

Article Abstract:

A study was conducted to demonstrate that expression and retrotransposition of specific telomeric repeats is under control of an RNAi-based system in the Drosophila germline. It showed that the double-stranded RNA (dsRNA)-mediated control of telomeric retroelement transposition might occur at premeiotic stages, resulting in the maintenance of appropriate telomere length in gamete precursors.

Physiological aspects, Genetic aspects, Retrotransposons

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Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect

Article Abstract:

The omission of drosophila chromosomes can be ideally sheltered from the end to end fusion, even if the complete telomere related series is not present. The absence of Ataxia Telangiectasia Mutated (ATM) lessens the amount of heterochromatin protein 1 (HP1) at telomeres and holds back the impact of telomere position.

Ataxia telangiectasia

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Telomere identity crisis

Article Abstract:

The mechanisms that are employed by normal telomeres to effectively protect chromosome ends from DNA repair pathways are studied. It is proposed that maturation of a DNA end into a functional telomere relies on recruitment of protein factors, which includes the anticheckpoint activity.

DNA repair

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