The Caenorhabditis elegans SH2 domain-containing protein tyrosine phosphatase PTP-2 participates in signal transduction during oogenesis and vulval development

Article Abstract:

A Caenorhabditis elegans gene, ptp-2, has been characterized. It encodes a 668-amino acid protein tyrosine phosphatase (SHP). A recessive ptp-2 loss-of-function allele, op194, lacking the conserved protein tyrosine phosphatase (PTP) catalytic domain has been isolated. Certain phenotypes show that PTP-2 activity is needed for proper oogenesis. PTP-2 function in C. elegans vulval cell differentiation seems to be directed at regulating overall strength of the inductive signal, which may contribute to the quantitative differences in signaling needed for specification of vulval cell fates.

Vulva, Phosphatases, Oogenesis

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Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor

Article Abstract:

A neurosecretory pathway controls a reversible developmental arrest and metabolic shift in the dauer larval stage of Caenorhabditis elegans. Defects in a signaling pathway like that of insulin cause arrest. Akt/PKB transduces signals like those of an insulin receptor to the DAF-16 transcription factor from AGE-1 PI3 kinase.

Insects, Molecular biology, Insulin, Insulin receptors

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A requirement for NF-kB activation in Bcr-Abl-mediated transformation

Article Abstract:

NF-kB is an important factor in Bcr-Abl signaling. It is likely that Bcr-Abl transformation and affected leukemias are affected by NF-kb modified genes.The experiment proves that NF-kB is needed for Bcr-Abl-mediated tumorigenicity in nude mic and for transformation of primary bone marrow cells.

Leukemia research

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