The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionarily conserved signaling pathway

Article Abstract:

Dorsal closure in Drosophila embryos takes place in late stages of embryogenesis. It involves modifications in cell shape that lead to juxtaposition and then adherence of the lateral epidermal primordia over the amnioserosa. Data indicate that homologs NCK-interacting kinase (NIK), mig-15, and misshapen are part of a signaling pathway conserved in flies, mammals, and worms to control developmentally regulated pathways. The Ste20-related kinase misshapen is necessary for Drosophila dorsal closure. It acts through a c-Jun amino-terminal kinase (JNK) mitogen-activated protein kinase (MAPK) module of signaling pathway conserved by evolution.

Research, Developmental genetics, Protein kinases

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Drosophila FACT contributes to Hox gene expression through physical and functional interactions with GAGA factor

Article Abstract:

Research has been conducted on chromatin structure which is important for the transcription regulation. The authors report that Drosophila FACT (facilitates chromatin transcription) is associated with GAGA factor via its subunit, binds to nucleotide and facilitates GAGA factor-directed chromatin remodeing.

Japan, Genetic regulation, Genetic research

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Osa-containing Brahma chromatin remodeling complexes are required for the repression of wingless target genes

Article Abstract:

Research demonstrates that in the absence of trithorax group gene osa, Drosophila expresses ectopically the Wing target genes and are suppressed by overexpressed osa. Data point out that chromatin structure regulation influences the target gene expression by the Wing gnes.

United States

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