The Drosophila nuclear receptor E75 contains heme and is gas responsive

Article Abstract:

A study is conducted to demonstrate that the ligand binding pocket of the Drosophila nuclear receptor E75 contains a heme prosthetic group. A correlation between the levels of E75 expression and the levels of available heme suggest a possible role as a heme sensor while the E-75-DHR3 interaction, regulated by the binding of NO or CO to the heme center, suggests that E75 may also function as a diatomic gas sensor.

Gene expression, Ligand binding (Biochemistry)

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Facilitated transport of a Dpp/Scw heterodimer by Sog/Tsg leads to robust patterning of the Drosophila blastoderm embryo

Article Abstract:

Short gastrulation (Sog) and twisted gastrulation (Tsg) play essential roles in transporting Decapentaplegic (Dpp) to the dorsal-most cells. The use of broadly distributed Dpp/Screw (Scw) homodimers produces the biphasic signal that is responsible for specifying the two dorsal tissue types is proposed.

Gastrulation, Protein research

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Temporal regulation of planar cell polarity: Insights from the Drosophila Eye

Article Abstract:

A first regulatory link between planar cell polarity (PCP) signaling and apical-basal polarity is identified. A component of the apical Crumbs complex that regulates the phosphorylation of the Frizzled (Fz) PCP receptor, thus modulating PCP in the Drosophila eye is proposed.

Cells, Phosphorylation, Cell motility

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