The alpha(1,3)Fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-,E-, and P-selectin ligand biosynthesis

Article Abstract:

Mice deficient in the Fuc-TVII locus were studied to address the uncertainty about the relative roles of Fuc-TIV and Fuc-TVII in the biological and pharmacological control of selectin ligand expression. Certain observations show that Fuc-TVII plays a major role in the biosynthesis of the E-,P-, and L-selectin counterreceptors' oligosaccharide portions. In addition, alpha(1,3)linked fucose moieties were implicated as essential components of L-selectin ligands on high endothelial venules. Fuc-TVII's pivotal regulatory role in leukocyte trafficking is implied.

Biosynthesis, Ligands (Biochemistry), Leukocytes, White blood cells

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Developmentally regulated glycosylation of the CD8(alpha)(beta) coreceptor stalk modulates ligand binding

Article Abstract:

Research has been conducted on the glycan structural changes associated with the cellular differentiation. The role of the glycan adducts to the O-glycosylated polypeptide stalk tethering the CD8(alpha)(beta) coreceptor to the thymocyte surface has been investigated and the results are reported.

Statistical Data Included, Oxygen, Glycosylation, Ligand binding (Biochemistry), Polypeptides, Cell research, Cytological research

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Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta1,3-N-acetylglucosaminyltransferase

Article Abstract:

Results demonstrate that Core1-beta3GlcNAcT and its cognate sulfated extended core1 O-glycans mediate the expression of MECA-79-positive, HEV-specific L-selectin ligands involved in the lymphocyte homing.

Japan, Cell receptors, Cell adhesion, Lymphocytes, Homeostasis

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