The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast

Article Abstract:

In budding yeast the conserved protein kinase Ipl1 regulates microtubule binding to kinetochores. Chromosome segregation is based on kinetochores, structures that mediate chromosome attachment to the mitotic spindle. Mutants in IPL1, which encodes a protein kinase, have been isolated in a screen for budding yeast mutants with defects in sister chromatid segregation and separation.

Germany, Observations, Cellular signal transduction, Microtubules, Chromosomes

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The budding yeast protein kinase Ipl1/Aurora allows the absence of tension to activate the spindle checkpoint

Article Abstract:

Research has been conducted on the spindle checkpoint which prevents cell cycle progression in cells. Results indicate that the budding yeast member of the Aurora protein kinase family, Ipl1, maintains the spindle checkpoint arrest subset induced by the protein kinase overexpression.

Statistical Data Included, Gene expression

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Recruitment of Thr 319-phosphorylated Ndd1p to the FHA domain of Fkh2p required Clb kinase actuivity: a mechanism for CLB cluster gene activation

Article Abstract:

Research has been conducted on CLB cluster gene activation which is important for mitotic entry and transition through M phase. The authors demonstrate that the mitotic transcriptional program activation depends on the recruitment of Ndd1p coactivator that functions via Fkh2p.

Australia, Food preparations, not elsewhere classified, All Other Miscellaneous Food Manufacturing, Brewers' Yeast, Genetic transcription, Transcription (Genetics), Phosphorylation, Brewer's yeast, Saccharomyces cerevisiae

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