NF1 tumor suppressor gene function: narrowing the GAP

Article Abstract:

The authors present a review of the publications on the tumor suppressor genes identified via their association with a familial cancer syndrome. The subjects of interest include NF1 and peripheral nerve sheath tumor, nerve and tumor development and the effect of the second-hit mutations on the tumor development.

Statistical Data Included, Growth, Tumors, Tumor suppressor genes

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Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired Pemphigus vulgaris

Article Abstract:

Research has been conducted on cell adhesion and communication. The authors report that desmoglein 4 is a mediator of keratinocyte cell adhesion in the hair follice, and that it coordinates transition from proliferation to differentiation.

Science & research, Research, Causes of, Genetic aspects, Cell differentiation, Morphogenesis, Keratinocytes, Cell adhesion, Cell proliferation, Pemphigus, Hair follicles

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