The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis

Article Abstract:

Results show that hepatitis B virus encoded oncoprotein pX, regulates cytokine transforming growth factor-beta (TGF-beta) signaling implicated in the pathogenesis of liver fibrosis. Data indicate that signal amplification of TGF-beta is accomplished by its complexing with the signal transduer Smad4 and an oncoprotein.

South Korea, Israel, Liver diseases, Hepatitis B virus

---

Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN

Article Abstract:

Results show that the Smad proteins, Smad2 and Smad3 degrade the transforming growth factor beta regulator protein SnoN, which is mediated by the anaphase-promoting complex and ubiquitin-conjugating enzymes. Data reveal that ubiquitination and degradation of SnoN requires the Smad3 binding site in SnoN and lysine residues of SnoN.

Canada, Enzymes, Ubiquitin, Enzyme regulation

---

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

Article Abstract:

Hepatocyte growth factor and epidermal growth factor signal through transmembrane receptor tyrosine kinases and facilitate gene activation. This activation is normally induced by Smad proteins through receptor serine-threonine kinases of the TGF-B superfamily. Experiments with mutations indicate that Smad2 may be a common factor in both processes and therefore in the process of phosphorylation.

Analysis, Genetic aspects, Proteins, Phosphorylation, Transduction, Transduction (Genetics)

Similar abstracts:

• Abstracts: Use of green fluorescent protein (GFP) to study the invsion pathways of Edwardsiella tarda in in vivo and in vitro fish models
• Abstracts: The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes
• Abstracts: Promoter opening by sigma(super.54) and sigma(super.70) RNA polymerases: sigma factor-directed alterations in the mechanism and tightness of control
• Abstracts: In vitro and in vitro survival and transit tolerance of potentially probiotic strains carried by artichokes in the gastrointestinal tract
• Abstracts: 'Puckered' encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.