The hypoxic response: huffing and HIFing

Article Abstract:

The molecular basis for the effect of hypoxia on animal life has gained the interest of biologists. Investigations have led to the recognition of hypoxia as a signal for energy conservation as well as an activator of genes responsible for the expression of the isoforms of glycolytic enzymes, glucose transporters that function better at low oxygen levels and erythropoietin (EPO). The hypoxia inducible factor 1 (HIF-1), on the other hand, has been identified as the transcription factor which specifically binds to the EPO enhancer. Results of further studies also proved HIF-1 as the global regulator of hypoxic gene expression.

Analysis, Usage, Hypoxia, Anoxia, Genetic regulation, Genetic transcription, Transcription (Genetics), Molecular biology, DNA binding proteins

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branchless encodes a Drosophila FGF homolog that controls tracheal cell migration and the pattern of branching

Article Abstract:

The role of the branchless (bnl) gene in regulating the development of the insect tracheal system was analyzed in Drosophila mutants with misexpressed bnl gene. The bnl mutants exhibited defective or aberrant tracheal branching with unbranched elongated tracheal metameres. The lethal mutations indicated the role of Drosophila bnl gene in regulating the development of the insect tracheal system by encoding fibroblast growth factors that promote tracheal cell migration.

Developmental biology, Cell migration, Trachea

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Sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways

Article Abstract:

Research was conducted to characterize sprouty, a key regulator of apical branching of the Drosophila airways and antagonist of fibroblast growth factor (FGF) signaling. Sibling control trains were analyzed with genomic fragments while developmental Northern blots were determined by phenol/chloro-form extraction of total RNA. Results indicated that the overactivity of the FGF homolog pathway led to a relaxation in the normal apical restriction to branching.

Research

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