The interaction between HIV-1 Tat and human cyclin T1 requires zinc and a critical cysteine residue that is not conserved in the murine CycT1 protein

Article Abstract:

HIV-1 Tat activates transcription by binding to human cyclin T1, which is a regulatory part of the TAK/P-TEFb CTD kinase complex. The cyclin domain of hCycT1 has been found to be necessary to interact with Tat in promoting cooperative binding to TAR RNA in vitro. It also mediates Tat transactivation in vivo. A Tat:TAR recognition motif (TRM) has been identified at the cyclin domain carboxy-terminal edge. In vitro it has been shown that hCycT1 can interact with Tat and CDK9 at the same time on TAR RNA.

United States, HIV infection, HIV infections, Genetic aspects, Observations, Proteins, Cellular signal transduction, Genetic regulation, Genetic transcription, Transcription (Genetics), RNA, Protein kinases, Binding sites (Biochemistry), Active sites (Biochemistry), Zinc in the body, Zinc (Nutrient), Viral genetics, Cysteine

---

Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses

Article Abstract:

Researchers have discovered a new ICAM-3 receptor on dendritic cells called DC-SIGN. DC-SIGN is a C-type lectin that mediates the transient adhesion of the dendritic cell to T cells.

Cell adhesion molecules

---

DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells

Article Abstract:

DC-SIGN appears to bind HIV-1 in mucosal tissues and present it to T cells, leading to an infection of the T cell. DC-SIGN is a C-type lectin that binds to ICAM-3 on resting T cells.

HIV (Viruses), HIV, Virus receptors

Similar abstracts:

• Abstracts: Congruence between allozyme and RAPD data in assessing macrogeographical genetic variation in the periwinkle Littorina striata (Mollusca, Gastropoda)
• Abstracts: Interactions between carbon and nitrogen metabolism in Fibrobacter succinogenes S85: a 1H and 13C nuclear magnetic resonance and enzymatic study
• Abstracts: Tn7 recognizes transposition target structures associated with DNA replication using the DNA-binding protein TnsE
• Abstracts: Development and characterization of DNA sequence OmyP9 associated with the sex chromosomes in rainbow trout. Sperm development, age and sex chromosome meiotic drive in the stalk-eyed fly, Cyrtodiopsis whitei
• Abstracts: Microsatellite Variation in Japanese and Asian Horses and Their Phylogenetic Relationship Using a European Horse Outgroup

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.