The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism

Article Abstract:

The major cytoplasmic histone acetyltransferase activity of Saccharomyces cerevisiae is biochemically isolated. The two major components of the activity are identified. The first component is shown to encode the catalytic subunit and the second encodes a protein required for high affinity binding of the acetyltransferase to histone H4. The findings provide new information on the acetylation and general metabolism of histones.

Cytoplasm

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Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta

Article Abstract:

This paper examines telemerase function in the cell by deveeloping an in vivo assay technique. Results show that addition of teleomere by telemerase in vivo is cell cycle-dependent and requires alpha and delta components of DNA polymerases and DNA primase.

Methods, Telomeres, Telomerase, Microbiological assay

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The histone minority report: the variant shall not be silenced

Article Abstract:

This article discusses the role of the histone variant H2A.Z within euchromatin in preventing silent chromatin from migrating to transcriptionally active regions in the chromosome.

Analysis, Influence, Genetic aspects, Chromatin, Proteins, Chromosomes, Structure

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