The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis

Article Abstract:

Apoptosis enables cells to get rid of useless and superfluous cells. Human bcl-2 proto-oncogene contributes to oncogenesis by preventing apoptosis. The role of bcl-2 in regulating apoptosis in the developing nervous system was analyzed using in vitro cranial sensory and autonomic motor neurons of the chicken embryo. Results showed that bcl-2 DNA microinjection into neurotrophic factor-deprived neurons does not result in apoptosis in ciliary neurons dependent on brain-derived neurotrophic factor. However, bcl-2 prevents apoptosis in neurons dependent on nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3.

Genetic aspects, Cellular control mechanisms, Cell regulation, Carcinogenesis, Proto-oncogenes

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Trigeminal sensory neurons require extrinsic signals neurotrophin dependence during the early stages of target field innervation

Article Abstract:

The transfer of nerve growth factor (NGF) dependence requires extrinsic signals that act on embryonic mouse ganglion. Researchers cultured trigeminal neurons with brain-derived neuronal factor (BDNF), neurotropin-3 (NT3), neurotropin 4/5 (NT4/5) before the NGF dependence period. The neurons survived well after the NGF dependence period would have begun. Portions of the neurons were moved to NGF cultures at various times and died. Neurons started in the BDNF-NT3-NT4/5 culture medium and moved to NGF during the switchover period had a longevity that increased with age.

Nerves, Nerve growth factor

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NGF receptor expression in sensory neurons develops normally in embryos lacking NGF

Article Abstract:

An in vivo study conducted on mouse embryos shows that the expression of NGF receptors p75 and TrkA, transmembrane glycoproteins, and sensitivity of neurons is independent of NGF, a neurotropin. Mutants lacking the NGF gene show normal expression of p75 and TrkA in the trigeminal ganglia during the E11 to E13 stage of development. The survival of neurons induced by NGF is also similar in both the mutant and the wild-type embryos.

Nervous system, Developmental neurology

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