The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae

Article Abstract:

The reduced efficiency of the yeast multidrug resistance protein Pdr5p leads to the drug sensitivity of the ergosterol strains of Saccharomyces cerevisiae. This was observed in a study of the function of Pdr5p in isogenic strains of Saccharomyces cerevisiae that have disruptions in the large phases of the ergosterol biosynthesis pathway. Results show that the ability of Pdr5p to confer resistance to different drugs in ergosterol mutants was reduced. The membrane environment is thought to play a significant role in determining the drug resistance conferred by Pdr5p.

Research, Membrane proteins, Yeast, Saccharomyces, Yeast (Food product)

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A kirromycin-resistant EF-Tu species reverses streptomycin dependence of Escherichia coli strains mutated in ribosomal protein S12

Article Abstract:

A study was undertaken to describe the suppressor mutation localized in the elongation factor Tu (EF-Tu) which was similar to models of ribosome-EF-Tu-tRNA interaction at the decoding center. The elongation factor belongs to the guanosine triphosphatase superfamily and complexes aminoacyl-tRNA in the GTP-bound state. Results revealed that mutations in EF-Tu inhibited streptomycin dependence of S12 mutants. Also, the EF-TuAR mutation induced the suppression of streptomycin dependence of Escherichia coli strains.

Microbial mutation, Guanosine triphosphatase

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Arming the enemy: the evolution of resistance to self-proteins

Article Abstract:

This review examines the discovery of new and novel antibiotics based on the toxic peptide, the cationic antimicrobial peptides. Authors critically evaluate the claim of their efficacy and the inability of the bacteria to develop resistance to them. Research indicates that the claims are unjustified and introduction of them for general use may jeopardize one's natural defences against infection.

Canada, France, Innovations, Evaluation, Antibiotics, Physiological aspects, Design and construction, Peptides, Chemical properties, Infection control

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