The yin and yang of P-TEFb regulation: Implications for human immunodeficiency virus gene expression and global control of cell growth and differentiation

Article Abstract:

The manner in which Brd4 and HEXIM1 proteins and the 7SK small nuclear RNA reciprocally affect positive transcription elongation factor b's (PTEFb's) activity to globally control transcriptional elongation and the physiological consequences resulting from such dynamic regulation are described. The observation of opposing influences on cellular growth exerted by Brd4 and HEXIM1, support the idea that controlling the activity of the general transcription factor P-TEFb is central to the global regulation of cell growth and differentiation.

HIV (Viruses), HIV, RNA polymerases

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Translational control of viral gene expression in eukaryotes

Article Abstract:

Advances in molecular and genome analyses have paved the way for studying the mechanisms of translational control of viral gene expression in eukaryotic systems. This review discusses RNA-protein interaction, environmental influence on viral and cellular gene expression, parallel identification of transcriptionally and translationally regulated mRNAs with reference to herpes and influenza viruses.

Analysis, Eukaryotic cells, Cells (Biology), Eukaryotes, Enzymes, Viruses, Genetic regulation, Herpesviruses, Enzyme regulation, Genetic translation, Translation (Genetics), Influenza viruses

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Detection of and Response to signals involved in host-microbe interactions by plant-associated bacteria

Article Abstract:

Diverse interactions between hosts and microbes are initiated by the detection of host-released chemical signals. The detection of these signals leads to altered patterns of gene expression that culminate in specific and adaptive changes in bacterial physiology that are required for these associations.

Pseudomonas syringae

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