A TRF1:BRF complex directs Drosophila RNA polymerase III transcription

Article Abstract:

Research has been conducted on the TATA binding protein (TBP). Results indicate that TBP-related factor TRF1 is responsible for Drosophila RNA polymerase III transcription.

United States, Statistical Data Included, Analysis, RNA polymerases, Drosophila, Cell research, Cytological research

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Human TAFII105 is a cell type-specific TFIID subunit related to hTAFII130

Article Abstract:

Previous research has shown that transcription factor TFIID isolated from Drosophila and human cells consists of TATA box-binding protein (TBP) and eight or more tightly associated subunits (TAFs). In an extension of that study, the composition of TBP-TAF complexes isolated from several human cell lines representing different tissues are compared with each other to test the possibility that some of the subunits may be cell-type specific. The properties of one subunit, TAF 105, suggest that it is cell-type specific.

Genetic regulation

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Transcription properties of a cell type-specific TATA-binding protein, TRF

Article Abstract:

The transcriptional and biochemical properties of TBP-related factor (TRF) were studied to prove that it could substitute the function of TATA-binding protein (TBP). Results show that the transcriptional activities of TRF was capable of interacting with TATA DNA binding complex such as TFIIA and TFIIB through protein-protein- and protein-DNA-binding tests. Biochemical properties of TRF were also proven to represent the properties of TBP and could therefore be substituted in the process of starting direct transcription by RNA polymerase II.

DNA, Eukaryotic cells, Cells (Biology), Eukaryotes, Carrier proteins, Transport proteins

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