Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements

Article Abstract:

A study to investigate the multipotent hematopoietic cells that are highly susceptible to alternative double-strand break repair pathways, promoting the genome rearrangements. Results show that these progenitor cells lead to the formation of chromosomal arrangements, promoting the several oncogenic events following DNA damage.

DNA repair, Genetic recombination, Translocation (Genetics), Hematopoietic stem cells, Translocations (Genetics), Clinical report

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To proliferate or to die: Role of Id3 in cell cycle progression and survival of neural crest progenitors

Article Abstract:

The helix-loop-helix transcriptional regulator Id3 has a novel role in cell cycle progression and survival of neural crest progenitors in Xenopus. Data suggests that Id3 functions by a novel mechanism, independent of cell fate determination, to mediate the decision of neuronal crest precursors to proliferate or die.

United States, Cell cycle, Neural crest

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