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Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120

Article Abstract:

Research has been conducted on HIV-1 coreceptor CCR5. The role of sulfated tyrosines in this receptor has been investigated, and the results demonstrate that the primary receptor CD4-induced HIV-1 nutralizing antibodies emulate CCR5, and that tyrosine sulfation contributes to the potency of the human humoral response.

Author: Burton, Dennis R., Farzan, Michael, Rosenberg, Eric S., Kwong, Peter D., Choe, Hyeryun, Li, Wenhui, Wright, Paulette L., Vasilieva, Natalya, Venturi, Miro, Huang, Chih-Chin, Grundner, Christoph, Dorfman, Tatyana, Zwick, Michael B., Wang, Liping, Robinson, James E., Sodroski, Joseph G.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
HIV antibodies

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CCR5 mimicry by sulfated human anti-HIV-1 antibodies

Article Abstract:

The authors discuss the study on HIV-1 envelope glycoprotein which requires sulfated tyrosines on the CCR5 amino terminus during its interaction with coreceptor CCR5. The topics of interest include the analysis of tyrosine-sulfated neutralizing antibodies against HIV-1 which mimics CCR5.

Author: Lin, George, Hoxie, James A.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2003
Antiviral agents, Mimicry (Biology), Anti-HIV agents, Viral antibodies, Antibodies

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Crystal structure of a complement control protein that regulates both pathways of complement activation and binds heparin sulfate proteoglycans

Article Abstract:

Research has been conducted on the vaccinia virus complement control protein inhibiting the complement activation pathways. Results indicate that the structure of the complement regulation intact regulator will stimulate the design of the therapeutic complement inhibitors.

Author: Smith, Scott A., Murthy, Krishna H. M., Ganesh, Vannakambadi K., Judge, Ken W., Mullin, Nick, Barlow, Paul N., Ogata, Craig M., Kotwal, Girish J.
Publisher: Elsevier B.V.
Publication Name: Cell
Subject: Biological sciences
ISSN: 0092-8674
Year: 2001
United Kingdom, Statistical Data Included, Viruses, Proteins, Heparin, Proteoglycans

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Subjects list: United States, Analysis, Physiological aspects, Genetic aspects, Glycoproteins, Cell research, Cytological research, Amino acids, Tyrosine, Sulfates
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