Ump1p is required for proper maturation of the 20S proteasome and becomes its substrate upon completion of the assembly

Article Abstract:

Research was conducted to describe the discovery of a proteasome maturation factor that is sensitive to a number of stresses. Characterized by a short in vivo half-life due to degradation, Ump1p plays an important role in coordinating the physical assembly and enzymatic activation of proteasomes. It has a molecular mass of 300-400 kDa and migrates faster in native gels than the 20S proteasome. It also accumulates Ub-protein conjugates while encoding a polypeptide with a calculated molecular mass of 16.8 kDa.

Ubiquitin

---

Dynamin: a molecular motor with pinchase action

Article Abstract:

Various studies have been carried out to examine how the dynamin family of proteins produces a compression force. These studies utilized cell-free systems, collared invaginations and tubular membrane intermediates to determine that the proteins are characterized by three distinct genes supporting several conserved motifs. Researchers are urged to conduct more studies designed to analyze how dynamin assembly and activity are regulated.

---

Degradation signal masking by heterodimerization of MAT-alpha-2 and MATa1 blocks their mutual destruction by the ubiquitin-proteasome pathway

Article Abstract:

A study was conducted to test whether a1 is degraded in haploid cells. HindIII fragments supporting either the MAT-alpha or MATa loci were subcloned into low and high-copy shuttle plasmids. Results indicated that degradation determinants in a1 and alpha-2 are masked in the heterodimer. Findings also showed that the correlation between alpha-2 and a1 depend on N-terminal coiled-coil interactions.

Research, Cells (Biology), Plasmids, Cells, Haploidy

Similar abstracts:

• Abstracts: Statistical approach for comparison of the growth rates of five strains of Staphylococcus aureus. Rapid biosensor of detection of antibiotic-selective growth of Escherichia coli
• Abstracts: A method for identification of the expression mode and mapping of QTL underlying embryo-specific characters. Mapping and Exclusion Mapping of Genomic Imprinting Effects in Mouse F2 Families
• Abstracts: Respiration of Pseudomonas fluorescens as a function of intracellular substrate concentration. The non-haem chloroperoxidase from Pseudomonas fluorescens and its relationship to pyrrolnitrin biosynthesis
• Abstracts: The origins of V(D)J recombination. Evolution of simple repeats in DNA and their relation to human disease
• Abstracts: Protein translocation in the three domains of life: Variations on a theme. part 2 Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.