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An iterative statistical approach to the identification of protein phosphorylation motifs from large-scale data sets

Article Abstract:

A study presents an algorithm designed to extract motifs from large data sets of naturally occurring phosphorylation sites, a method that relies on the intrinsic alignment of phospho-residues and the extraction of motifs through iterative comparison to a dynamic statistical background. Results demonstrate the identification of dozens of novel and unknown phosphorylation motifs from newly published serine, threonine, and tyrosine phosphorylation studies.

Author: Gygi, Steven P., Schwartz, Daniel
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
Phosphorylation, Tyrosine

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RNA synthetic biology

Article Abstract:

Researchers have produced a novel, synthetic RNA components that are capable of regulating gene expression in vivo largely in bacteria and yeast, which have set stage for scalable and programmable cellular behavior. The immediate challenges, future directions and applications of engineered RNA-based systems are discussed.

Author: Collins, James J., Dwyer, Daniel J., Isaacs, Farren J.
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
RNA

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From words to literature in structural proteomics

Article Abstract:

The integrated strategies and tactics that can be used for characterizing molecular complexes and for describing their interactions in a cellular context are presented. A comprehensive description of the multitude of interactions between molecular entities is given.

Author: Sali, Andrej, Baumeister, Wolfgang, Glaeser, Robert, Earnest, Thomas
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2003
Proteomics, Structure

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Subjects list: Research, United States, Molecular biology
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