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Fluorogen-activating single-chain antibodies for imaging cell surface proteins

Article Abstract:

The development of protein reporters that generate fluorescence from otherwise dark molecules (fluorogens) is described. The eight unique fluorogen activating proteins (FAPs) from a collection of human single-chain antibodies (scFvs) are presented applying derivatives of thiazole orange and malachite green.

Author: Bruchez, Marcel P., Szent-Gyorgyi, Christopher, Schmidt, Brigitte A., Creeger, Yehuda, Fisher, Gregory W., Zakel, Kelly L., Adler, Sally, Fitzpatrick, James A. J., Woolford, Carol A., Qi Yan, Vasilev, Kalin V., Berget, Peter B., Jarvik, Jonathan W., Waggoner, Alan
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2008
Analysis, Fluorescence, Protein research, Viral antibodies, Antibodies

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Improved antimicrobial peptides based on acyl-lysine oligomers

Article Abstract:

A supplementary table method is designed in which the oligomers have acyl chains that prevent the formation of stable secondary structure. The results show improved antimicrobial peptides.

Author: Navon-Venezia, Shiri, Carmeli, Yehuda, Radzishevsky, Inna S., Rotem, Shahar, Bourdetsky, Dmitry, Mor, Amram
Publisher: Nature Publishing Co.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
Lysine, Oligomers, Antimicrobial additives, Chemical properties

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