RNAi in moderation
Article Abstract:
The enthusiasm surrounding RNA interference (RNAi) as a new therapeutic modality is tempered by a growing awareness of its potential to cause unwanted side effects. RNAi is found variously to induce 'off-target' gene silencing, to trigger an interferon response leading to global inhibition of translation, to stimulate nonspecific RNA degradation by RNase L and to activate toll-like receptors and retinoic acid-inducible gene 1 protein, both of which promote adverse immune reactions.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2006
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Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
Article Abstract:
A variety of lipophilic small interfering (si)RNAs are synthesized and used for elucidating the requirements for siRNA delivery in vivo. Results show that conjugation to lipophilic molecules enables effective siRNA uptake through a common mechanism that can be used for optimizing therapeutic siRNA delivery.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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