Recombinant protein folding and misfolding in Escherichia coli

Article Abstract:

The mechanisms used by Escherichia coli to support protein folding, manage stress-induced protein misfolding are also used to promote high-level production of heterologous proteins in a correct and bioactive conformation in the bacterial cytoplasm and periplasm. The principles that govern protein folding and misfolding in E. coli, the availability of sophisticated tools for chromosome engineering and rapid progress in PCR are described.

United States, Protein folding, Recombinant proteins

---

Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets

Article Abstract:

An important problem in industrial strain construction and a central tenet of metabolic engineering is the identification of genes that affect the product accumulation phenotype of recombinant strains. A study identifies gene knockout targets that increase lycopene biosynthesis in strains of Escherichia coli by using systematic (model-based) and combinatorial (transposon-based) methods.

DNA testing, DNA identification

---

Similar abstracts:

• Abstracts: Dotcom mania: the rise and fall of internet stock prices. Rumors
• Abstracts: Effect of combined dynamic and static workload on heart rate recovery cost. An investigation of stability limits while holding a load
• Abstracts: Sega's derby owners club in Ireland. Time is no longer waiting in the wings of capital city
• Abstracts: Temperature-sensitive control of protein activity by conditionally splicing inteins. Finding needles in haystacks

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.