Selective targeting and photocoagulation of ocular angiogenesis mediated by a phage-derived human antibody fragment

Article Abstract:

Useful for diagnosis and treatment of pathologies associated with angiogenesis are molecules that selectively target and occlude new blood vessels. Phage-derived human antibiody fragment (L19) with high affinity for the ED-B domain of fibronectin, a marker of angiogenesis, selectively localizes to newly formed blood vessels in a rabbit model of ocular angiiogenesis.

Italy, Pharmaceutical Preparation Manufacturing, Anticancer Drugs, Antineoplastic agents

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Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array

Article Abstract:

Oligonucleotides microarrays, known as "DNA chips" are presently made by a light-directed chemistry that necessitates a large number of photolithographic masks for each chip. In the present article a maskless array synthesizer (MAS) that replaces the chrome masks with virtual masks generated on a computer which are relayed to a digital micromirror array is used.

United States, Biological Product (except Diagnostic) Manufacturing, Wisconsin, Oligonucleotides, Nucleotides

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Directed evolution of human T-cell receptors with picomolar affinities by phage display

Article Abstract:

The display of ten different human T-cell receptors (TCRs) on the surface of bacteriophage, stabilized by a nonnative interchain disulfide bond is described. T cells specifically recognize peptide-human leukocyte antigen (pHLA) with their clonally rearranged TCRs, whose natural affinities are limited to ~1-100 mu(M)(super 1).

Research, Peptide hormones, Antigen receptors, T cell, T cell antigen receptors, T cells, Human cytogenetics

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