Stem and progenitor cell-based therapy of the human central nervous system
Article Abstract:
Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the cerebral ventricles of all adult animals, including humans. A number of approaches have evolved for using neural progenitor cells in cell therapy and four strategies are especially attractive for clinical translation, which together might represent the most compelling strategies, and near-term disease targets for cell-based neurological therapy.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2005
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Targeting brain-tumor stem cells
Article Abstract:
The mouse models of glioblastoma provide evidence supporting involvement of cancer stem cells in tumors of the brain and reveal the mechanisms by which stem cells escape antitumor treatment. The findings show that glioblastoma cells, in particular CD[133.sup.+] cells have a functional BMP receptor pathway.
Publication Name: Nature Biotechnology
Subject: Business
ISSN: 1087-0156
Year: 2007
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