The worm turns for antimicrobial discovery

Article Abstract:

Compounds that promote survival of Caenorhabditis elegan after persistent infection with Enteroccocus faecalis can either prevent persistence of the pathogen in the intestine or enable the host to tolerate chronic innocuous intestinal colonization. It is found that a striking difference in the appearance of live worms and worms that have succumbed to the infection facilitates high-throughput screening for antimicrobials.

Drug resistance in microorganisms, Microbial drug resistance

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Riboswitches as antibacterial drug targets

Article Abstract:

The experiments validating riboswitches as drug targets, the existing technology for riboswitch drug discovery and the challenges faced by riboswitch drug discoverers are presented. The existence of multiple riboswitch classes in a variety of bacterial pathogens has offered hopes that many distinct classes of new drugs could be developed to help replenish the arsenal of antibiotic compounds.

Bacteriostats, Antibiotics, Antibacterial agents

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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

Article Abstract:

The cationic amphiphilic peptides with antimicrobial and immunomodulatory activities have comprised potent and broad-spectrum molecules that have many desirable properties. The upregulation of innate immune mechanisms while suppressing pro-inflammatory cytokine responses has offered an exciting and novel method to anti-infective therapy.

Peptides, Immune response

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