Tumor targeting with a selective gelatinase inhibitor

Article Abstract:

Several streams of evidence suggest that tumor growth, angeogenesis, and metastasis are dependent on matrix metalloproteinase (MMP) activity. The lack of inhibitors specific for the type IV collagenase/gelatinase family of MMPs has so far prevented the selective targeting MMP-2 (gelatinase A) and MMP-9 (gelatinaseB) for therapeutic intervention in cancer.

Pharmaceutical Preparation Manufacturing, Anticancer Drugs, Antineoplastic agents

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Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase

Article Abstract:

Cbl is an adaptor protein that works as a negative regulator of many signaling pathways that begin from receptors at the cell surface. The evolutionarily conserved amino-terminal segment of Cbl (Cbl-N) binds to phosphorylated tyrosine residues and has cell transforming activity.

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In vivo near-infrared fluorescence imaging of osteoblastic activity

Article Abstract:

Researchers in the U.S. have synthesized a near-infrared fluorescent bisphosphonate derivative that can be used to image osteoblastic activity in vitro and in vivo that is faster than current technology, and produces a clearer image.

Diagnostic substances, Diagnostic Reagents

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