Atomic force microscopy and near-field scanning optical microscopy measurements of single human retinal lipofuscin granules

Article Abstract:

Studies done to characterize the spatial distribution of orange emitting fluorophores, such as, A2E, in lipofuscin granules isolated from human retinal pigment epithelium cells by using novel high-resolution microscopic techniques is reported. Granules are imaged using atomic force microscopy (AFM) and near field- scanning optical microscopy (NSOM) and the results demonstrate that the orange fluorophores may not be the dominant photoactive species in lipofuscin.

Analysis, Epithelial cells, Atomic force microscopy

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Photoionization threshold of eumelanosomes determined using UV free electron laser-photoelectron emission microscopy

Article Abstract:

The application of UV-free electron laser photoelectron emission microscopy (UV-FEL PEEM) to measure the threshold photoelectron spectrum and photoionization potential for human eumelanosomes is described. The UV-FEL PEEM images collected on human eumalenasomes isolated from black hair show that the organelle is photoionized by UV-B radiation and the photoionization threshold is determined to be 4.6 plusmn 0.2eV.

Usage, Chemistry, Physical and theoretical, Physical chemistry, Electrons, Photoelectron spectroscopy, Ionization

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Carotenoid radical-melanin interactions

Article Abstract:

The radical cations of five dietary carotenoids are shown to react with dopamelanin and cysteinyldopamelanin in both micellar and homogenous environments. The previously unidentified protective roles for melanin/carotenoid combinations are demonstrated by the repair reactions, especially where the maintenance of the small carotenoid concentration is vital to avoid deleterious effects.

Melanin, Carotenoid metabolism

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