Cholesterol supports headgroup superlattice domain formation in fluid phospholipid/cholesterol bilayers

Article Abstract:

A study provides spectroscopic evidence that regular, superlattice-like arrangements at certain critical lipid compositions in phospholipid bilayers exist at the headgroup and acyl chain levels for fluid state phosphatidylethanolamine/phosphatidylcholine (PE/PC)/cholesterol. Since PE, PC, and cholesterol are major lipid components of mammalian cell membranes, the existence of superlattice-like domains at both the headgroup and the acyl chain is involved in the regulation of lipid compositions and other lipid domain-mediated membrane activities.

Amines

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Water concentration profiles in membranes measured by ESEEM of spin-labeled lipids

Article Abstract:

The penetration of water (D2O) into bilayer membranes of dipalmitoyl phosphatidylcholine with and without 50 mol% cholesterol is detected using electron spin-echo envelope modulation (ESEEM) spectroscopy of phospholipids spin-labeled systematically down the sn-2 chain. Three-pulse stimulated echoes allow the resolution of two superimposed (super 2)H-ESEEM spectral components of different widths, for spin labels located in the upper part of the lipid chains.

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Echo-detected electron paramagnetic resonance spectra of spin-labeled lipids in membrane model systems

Article Abstract:

Pulsed electron paramagnetic resonance (EPR) spectroscopy is used to investigate the dynamics of spin-labeled lipid chains in the low-temperature phases of dipalmitoyl phosphatidylcholine (DPPC) membranes, with and without equimolar cholesterol. A comparative study of two-pulse and three-pulse ED-EPR spectra reveals the presence of a wide distribution of correlation times for the librational chain motions in the low-temperature phases of lipid membranes.

Analysis, Usage, Lipids, Electron paramagnetic resonance spectroscopy, Atomic properties, Spin labeling

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