Steady state and time-resolved fluorescence investigation of the specific binding of two chlorin derivatives with human serum albumin

Article Abstract:

The specific binding of two model drugs for photodynamic therapy, namely chlorin [p.sub.6] and purpurin 18 in the vicinity of Sudlow's Site I of HSA is examined by monitoring the intrinsic fluorescence of single tryptophanyl residue and by competitive binding with warfarin. Time-resolved fluorescence results of competitive binding with warfarin have confirmed that they bind to the warfarin binding site.

Health aspects, Cancer, Photochemotherapy

---

Structure of the ochratoxin A binding site within human serum albumin

Article Abstract:

Theoretical simulations and site-directed mutagenesis experiments examine the binding site of ochratoxin A (OTA) within domain of 2A of human serum albumin. R257 plays an important role in the binding of the isocoumarin ring of OTA by serving as a proton acceptor and stabilizing the binding through the creation of an ion pair with the phenoxide group on OTA.

Methods, Mutagenesis, Chemical properties, Phenyl compounds

---

Change of xi potential of biocompatible colloidal oxide particles upon adsorption of bovine serum albumin and lysozyme

Article Abstract:

The xi potentials and isoelectric points (IEPs) are measured for alumina, silica, titania, and zirconia and correlated with the protein amount adsorbed at pH 7.5. The results revealed that zirconia adsorbs the highest protein amount even under repulsive electrostatic conditions in the case of bovine serum albumin (BSA).

Switzerland, Lysozyme, Zirconium oxide

Similar abstracts:

• Abstracts: Optical absorption and photoluminescence studies of free-standing porous silicon films with high porosities. Environmental effects on photoluminescence of highly luminescent CdSe and CdSe/ZnS core/shell nanocrystals in polymer thin films
• Abstracts: Evaluating the influence of deposition conditions on solvation of reactive conducting polymers with neutron reflectivity
• Abstracts: Calculation of the bulk modulus of simple and complex crystals with the chemical bond method. Study on optical properties of rare-earth ions in nanocrystalline monoclinic SrAl2O4: Ln [Ln=Ce(super 3+), Pr(super 3+), Tb(super 3+)]
• Abstracts: Effects of dipole moment, linkers, and chromophores at side chains on long-range electron transfer through helical peptides
• Abstracts: Phase segregation in cerium-lanthanum solid solutions. MnO(sub 2-) embedded-in-mesoporous-carbon-wall structure for use as electrochemical capacitors

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.