Direct cellular responses to platinum-induced DNA damage

Article Abstract:

The article reviews cellular processes that lead to the formation of platinum-DNA adducts and the early events that subsequently transpire. Information on how platinum complexes enter cells are used to discuss the interactions of cellular proteins with platinum-DNA adducts.

Science & research, Primary nonferrous metals, not elsewhere classified, Primary Smelting and Refining of Nonferrous Metal (except Copper and Aluminum), Pharmaceutical Preparation Manufacturing, Pharmaceutical preparations, Anticancer Drugs, Platinum, Chemotherapeutic Drugs, Research, Antineoplastic agents, DNA damage, Properties, Structure, Antimitotic agents

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Structure, recognition, and processing of cisplatin-DNA adducts

Article Abstract:

Researchers are still trying to determine exactly how cisplatin destroys cancer cells. The drug binds to DNA and several proteins have been identified that bind to the cisplatin-DNA adduct. These proteins may be involved in the drug's activity against cancer cells.

Health aspects, Physiological aspects, Inorganic compounds, Cisplatin

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Synthetic models for non-heme carboxylate-bridged diiron metalloproteins: strategies and tactics

Article Abstract:

Metalloproteins that are identified to share the carboxylate-bridged diiron active site motif are listed. The activation of dioxygen by diiron (II) compounds that lead to the formation of interesting intermediates is described.

Analysis, Metalloproteins, Chemical synthesis

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