Modular peptide synthetases involved in nonribosomal peptide synthesis

Article Abstract:

Understanding of the structures and synthesis of bioactive peptides produced via ribosomal and nonribosomal mechanisms has progressed. The nonribosomal peptide synthetic route is now generally accepted as an alternative way of manufacturing highly specialized polypeptides. The functional domains of modular peptide synthetases are described.

Observations, Biosynthesis

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Vibrational spectroscopic detection of beta- and gamma-turns in synthetic and natural peptides and proteins

Article Abstract:

The authors review the publications on proteins, peptides, and their derivatives. The topics of interest include the applications of vibrational spectroscopy for conformational characterization of proteins and peptides, and the detection of H-bonding in turns.

France, Analysis, Usage, Proteins, Protein synthesis, Conformational analysis, Peptide synthesis, Chemical research, Chemical bonds, Properties, Vibrational spectra, Structure, Chemical properties

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The chemistry of 2-aminocycloalkanecarboxylic acids

Article Abstract:

Research has been conducted on the alicyclic beta-amino acids. The synthetic strategies that involve transformations of these acids to heterocycles, peptides or peptidomimetics have been developed and discussed.

Statistical Data Included, Research, Heterocyclic compounds, Amino acids, Pharmaceutical chemistry

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