Synthesis of complex nucleoside antibiotics

Article Abstract:

Complex nucleoside antibiotics are an important natural product. An analysis of the methods used to prepare such antibiotics using the examples thuringiensin and octosyl acid A is given. The synthesis involves preparing different parts of the antibiotics using protecting groups, combining these parts and then removing the protecting groups. Although the best method is combining different complex parts at the end of the process, this is experimentally not easy. The protecting groups help in the formation of the individual parts and control their stereochemistry during combining. These antibiotics are antifungal, antiviral and antitumor substances.

Organic compounds, Organic compound synthesis

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Biosynthesis of the kinamycins

Article Abstract:

The study of the biosynthesis of the kinamycin antibiotics has mainly been at the structural level, but now it is also being undertaken at biochemical and molecular genetics levels. Kinamycins are diazo-substituted benzo(b)fluorenes and recent findings have used synthesized putative advanced intermediates. Aspects of kinamycin biosynthesis during the period 1970 to 1996 are reviewed.

Observations, Biosynthesis

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Strategy and methodology development for the total synthesis of polyether ionophore antibiotics

Article Abstract:

Research into the total synthesis of polyether ionophore antibiotics is presented. Future research may focus on developing more efficient and predictable techniques for fragment coupling.

Ionophores

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