Chemical synthesis of natural product peptides: coupling methods for the incporporation of noncoded amino acids into peptides

Article Abstract:

A study was conducted on reagents and approaches for natural product peptide synthesis with amino acids. Nonribosomal peptide synthesis can be achieved with Caprino's NATU and several other reagents. 9-fluorenylmethoxycarbonyl amino acid fluorides have also made solid phase synthesis of 2-aminoisonutyric acid much simpler. Schmidt's phosphonoglycine technique was observed to be the most versatile approach to dehyropeptide coupling.

Peptides, Peptide synthesis, Amino acids

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Synthetic applications of dialkyl (chloromethyl)phosphonates and N,N,N,N-tetraalkyl(chloromethyl)phosphonic diamides

Article Abstract:

Compounds of (chloromethyl)phosphonates are useful reagents and constituents in the synthesis of numerous functionalized phosphonates and nonphosphorylated organic materials, such as alkenes and alkynes. Such compounds can be used as olefination reagents in Horner-Wadsworth-Emmons reactions to produce organic substrates, and in the production of compounds with biological activities.

Analysis, Production management, Organic compounds, Organic compound synthesis, Olefins, Alkenes, Phosphonates, Chloromethyl group

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