Mining for biological activity

Article Abstract:

With the potential represented in soil metagenome libraries, exciting new natural product discoveries from screens can be expected. Microorganisms in the soil are a great source of drug discovery research material. Activities at the University of Wisconsin, Madison, Dept of Plant Pathology, in this area of investigation, focused on screening libraries for biological activities are discussed. Research efforts discussed are targeted toward developing a screening technique that will address three areas in the design of bacteria-based libraries. They are rate of screening throughput, access to intracellular molecules and ease of positive clone recovery. About 30,000 individually arrayed clones are being subjected to activity screens.

United States, Drugs & Pharmaceuticals, Biochemistry, Pharmaceutical and Medicine Manufacturing, Research and Development in the Physical, Engineering, and Life Sciences, Drugs, Medicinal and Botanical Manufacturing, Bulk Antibiotics, Medicinals and botanicals, Statistical Data Included, Research, Analysis, Usage, Product development, Biotechnology industry, Pharmaceutical industry, Biotechnology industries, Antibiotics, DNA, Cytochemistry

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Collaborations subcommittee keynote address

Article Abstract:

The construction industry is encouraged to cooperate on an industry-wide planning effort to help the US maintain its technology leadership position, keep a high standard of living and to create future employment opportunities. The industry should advocate partnership agreements with the government and its agencies to advance technology programs and construction projects. Moreover, It should promote collaborative investments in areas such as human resources, equipment and infrastructure, and research and technology development.

Social aspects, Construction industry, High technology industry, Investments, Cost and standard of living, Cost of living

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