Effect of glyburide on hepatic glucose metabolism
Article Abstract:
Non-insulin-dependent diabetes mellitus (NIDDM) is a disorder of glucose metabolism, which develops mainly in obese adults. This metabolic disorder is characterized by hyperglycemia, or increased blood levels of glucose, and glycosuria, the excretion of glucose in the urine, which results from the decreased utilization of glucose by the body. NIDDM is associated with a decreased responsiveness of the body's tissues to the actions of insulin, a protein hormone that controls the consumption of glucose by cells for the production of energy. Insulin is produced by the beta cells in the pancreas and released in response to a rise in blood levels of glucose. Drugs used to treat NIDDM such as glyburide compensate for the decreased responsiveness of tissues to insulin by increasing the release of insulin from the pancreas. Glyburide was shown to improve resting blood glucose levels and the glucose response to a meal. By increasing the release of insulin from the pancreas, glyburide decreases the production of glucose by the liver, which contributes to the effect of glyburide in lowering blood glucose levels. However, this effect of glyburide on the liver does not persist with continued treatment. Results suggest that glyburide may act directly on the liver. In test tube experiments with liver cells, glyburide was shown to prevent the production of glucose and the breakdown of glycogen, the storage form of glucose, and increase the uptake of glucose by liver cells. These findings may contribute to the understanding of the mechanism of action of glyburide on glucose metabolism in the liver. (Consumer Summary produced by Reliance Medical Information, Inc.)
Publication Name: American Journal of Medicine
Subject: Health care industry
ISSN: 0002-9343
Year: 1990
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Challenging conformity
Article Abstract:
A student who joined an environmental action group at a Catholic university believes many students and residents of small-town Middle America will fight for social causes once they are exposed to them. Most simply have not seen the positive changes activism can produce.
Publication Name: Environmental Action Magazine
Subject: Environmental issues
ISSN: 0013-922X
Year: 1993
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It's a no-brainer
Article Abstract:
Issues are presented concerning the research which is carried out into topics where the answer provided from the investigations seems very obvious. A number of such research projects are discussed.
Publication Name: Reader's Digest
Subject: General interest
ISSN: 0034-0375
Year: 2000
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