Changes in liver concentration of N-acetylglutamate and ornithine are involved in regulating urea synthesis in rats treated with thyroid hormone

Article Abstract:

Studies were made on the effect of thyroid hormones on urea synthesis in three sets of rats, which had diets with various types of thyroid hormones. Findings show a diet having 0.1% 6-propyl-2-thiouracil (PTU), a thyroid inhibitor, stimulated urea synthesis and raised liver concentration of N-acetylglutamate and ornithine. PTU probably accounts for the increased ornithine concentration by stepping up its catabolism. It also raises urinary excretion of urea. Rats treated with PTU plus triiodithyronine or those given no thyroid hormones at all showed similar reactions but to much lower degrees.

Thyroid hormones, Urea, Triiodothyronine

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Bile acid metabolism in rats fed two levels of corn oil and brans of oat, rye and barley and sugar beet fiber

Article Abstract:

The influence of fiber and fat on bile acid secretion was investigated. Rats were given diets containing rye bran, oat bran, barley bran or sugar beet fiber plus 5% or 20% corn oil. All fiber sources increased fecal output and decreased fecal bile acid levels, although effects of fiber from different sources showed considerable variation. Fat intake had no significant effect on bile acid secretion. Evaluation of bile acid excretion due to dietary modification is important because the high association between increased bile acid output and colon cancer may lead to misdiagnosis.

Corn oil, Bran

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Low protein diets potentiate lithocholic acid-induced cholestasis in rats

Article Abstract:

A study was done on the effects of low protein diets on lithocholic acid-induced cholestasis in rats. Results show that rats given low protein diets (LPD) showed lower bile flow and biliary acid output than control rats given adequate protein diet. It was further shown that lithocholic acid injection stimulated an immediate cholestatic response characterized by a 90% drop in bile flow in LPD-fed rats.

Cholestasis, Cholic acid, Low-protein diet, Protein restricted diet

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