Inhibition of cellular uptake of folate by blocking synthesis of the membrane folate receptor

Article Abstract:

Folate receptors are connected to plasma membranes through a glycosylphosphatidylinositol connector. They must have both sphingolipids and cholesterol in the membrane to be fully active. Treatment of cells in culture with the mycotoxin fumonisin B1 essentially stopped uptake of 5-methyltetrahydrofolate. Fumonisin B1 inhibits sphingolipid synthesis.

Physiological aspects, Folic acid, Mycotoxins, Sphingolipids

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Individual variability in homocysteine response to folate depletion: an unusual case

Article Abstract:

Elevated plasma homcysteine concentrations have been associated with an increased risk of vascular disease. This is cause by a variety of genetic and nutritional factors, the most influential is folate nutriture. The homocysteine response to folate can vary between individuals and further research is necessary.

Health aspects, Peripheral vascular diseases

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