Kinetics of human hemopoietic cells after in vivo administration of granulocyte-macrophage colony-stimulating factor

Article Abstract:

This study tracks the changes that occurred in human bone marrow and circulating blood cells following the administration of a colony stimulating factor, CSF (a protein produced by certain white blood cells which appears to be required for the production of white blood cells containing granules.) The patients used in this study had various tumors and normal bone marrow. They were treated with a CSF for 3 days prior to having chemotherapy. The treatment increased the number of certain white blood cells. Other blood elements did not change. The study suggests that CSF activates cells involved in the production of both red and white blood cells, but that only specific white cells are directly a target of the factor. The effect was rapidly diminished following the end of treatment.

Health aspects, Abnormalities, Causes of, Cellular control mechanisms, Cell regulation, Hematopoiesis, Carcinogenesis, Colony-stimulating factors (Physiology), Colony-stimulating factors

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Developmental changes in the relation between phosphate metabolites and oxygen consumption in the sheep heart in vivo

Article Abstract:

This experimental study examines the role of phosphate compounds (metabolites) in the regulation of the use of oxygen by the hearts of lambs and sheep by using an open chest procedure. The authors conclude that there are changes in phosphate metabolites in newborn animals which are not apparent in mature animals of the same species, and that these changes may be more important in regulation of heart muscle energy regulation in young animals.

Laws, regulations and rules, Heart, Energy metabolism, Laboratory animals, Sheep, Sheep as laboratory animals

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Prosomatostatin-derived antrin is present in gastric D cells and in portal blood

Article Abstract:

Antrin is a recently discovered prohormone associated with somatostatin, a compound located in certain cells lining the stomach. Use of the electron microscope did not allow these investigators to locate antrin in the same areas which have been previously shown to contain other somatostatins. The study also demonstrates that antrin circulates in the blood.

Blood cells, Somatostatin

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