A comparison of conservative and aggressive transfusion regimens in the perioperative management of sickle cell disease

Article Abstract:

Moderate blood transfusion of surgical sickle-cell-anemia patients may be as effective as heavy transfusion in preventing surgical complications. Furthermore, moderate transfusion may be less likely to cause transfusion complications. Researchers followed a moderate transfusion protocol with 301 surgical sickle-cell-patients, and heavy transfusion protocol with 303 surgical, sickle-cell-patients. Both transfusion protocols aimed to maintain a hemoglobin level of 10 grams/deciliter, but the heavy protocol also aimed to keep hemoglobin S levels below 30%. The rate of serious surgical complications was 35% in the moderate transfusion group and 31% in the heavy transfusion group. However, the rate of transfusion complications was 7% in the moderate transfusion group and 14% in the heavy transfusion group. Thus, moderate transfusion resulted in half as many transfusion complications as heavy transfusion.

Health aspects, Surgery, Blood transfusion

---

Pulmonary hypertension as a risk factor for death in patients with sickle cell disease

Article Abstract:

A study was conducted with 82 men and 113 women for a period of 18 months, to understand the prevalence of pulmonary hypertension in adults with sickle cell disease. The developmental mechanism and prognostic significance using Doppler echocardiography therapeutic trials are highlighted along with the results.

Risk factors

---

Pulmonary hypertension in sickle cell disease

Article Abstract:

The study revealed that sickle cell disease is complicated by pulmonary hypertension in about one third of adult patients. The two most common causes of death in patients with sickle cell disease are pulmonary hypertension and chronic lung disease.

Lung diseases

Similar abstracts:

• Abstracts: Bioequivalence of generic and brand-name levothyroxine products in the treatment of hypothyroidism. Triiodothyronine levels in athyreotic individuals during levothyroxine therapy
• Abstracts: Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa
• Abstracts: Abortion, health, and the law. The big chill--Inserting the DEA into end-of-life care. Inserting government between patient and physician
• Abstracts: Stem cell research: Paths to cancer therapies and regenerative medicine. Cancer vaccine research inches forward
• Abstracts: Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth. Fetal fibronectin and bacterial vaginosis are associated with preterm birth in women who are symptomatic for preterm labor

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.