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A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist

Article Abstract:

The biological actions of a ligand-receptor fusion of growth hormone and the extracellular domain of its receptor are analyzed. The studies have shown that a ligand-receptor fusion of cytokine to its extracellular receptor has generated a potent, long-acting agonist with exceptionally slow absorption and elimination.

Author: Artymiuk, Peter J., Strasburger, Christian J., Ross, Richard J., Wilkinson, Ian R., Ferrandis, Eric, Teillot, Marc, Soulard, Chantal, Touvay, Caroline, Pradhananga, Sarbendra L., Justice, Sue, Zida Wu, Leung, Kin C., Sayers, Jon R.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
Health aspects, Somatotropin, Somatotrophin

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Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1

Article Abstract:

The efficacy and safety of 10-d monotherapy with the orally administered CCR5 antagonist maraviroc in 63 HIV-1 positive individuals prescreened for the absence of CXCR4-using virus is assessed. Results provide a proof of concept that CCR5 is a viable antiretroviral therapeutic approach.

Author: Saag, Michael S., Rockstroh, Jurgen K., Pozniak, Anton, Staszewski, Schlomo, Hoepelman, Andy I.M., Fatkenheuer, Gerd, Johnson, Margaret A., Plettenberg, AndreasM, Geobel, Frank D., Dezube, Bruce J.M., Jenkins, Tim M., Medhurst, Christine, Sullivan, John F., Ridgway, Caroline, Abel, Samantha, James, Ian T., Youle, Mike, Ryst, Elna van der
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Care and treatment, Antiviral agents, Anti-HIV agents

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HIV-1 and HAART: a time to cure, a time to kill

Article Abstract:

HIV-1, long-lived, latently infected cells that evade immune detection, and highly active antiretroviral therapy, are discussed. Two clinical studies have shown failure of conventional anti-retroviral therapy to eradicate HIV, and it may take 10-60 years to eliminate HIV.

Author: Saag, Michael S., Kilby, J. Michael
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
United States, Evaluation, Drug therapy, Highly active antiretroviral therapy

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Subjects list: Research, Cytokine receptors, HIV infection, HIV infections
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