Splenic artery Doppler peak systolic velocity predicts severe fetal anemia in rhesus disease

Article Abstract:

The velocity of blood flow in the splenic artery of a fetus with rhesus disease can predict whether the fetus has anemia. In a study of 26 fetuses, blood flow greater than normal in the splenic artery detected all the fetuses known to be anemic from blood analysis.

Blood flow, Measurement, Blood flow measurement, Erythroblastosis fetalis

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A new splenic artery Doppler velocimetric index for prediction of severe fetal anemia associated with Rh alloimmunization

Article Abstract:

A Doppler velocimetric index can be used to noninvasively detect fetuses with severe anemia due to Rh incompatibility. This index uses Doppler ultrasound to measure blood flow in the spleen of the fetus. Researchers used the technique on 85 healthy fetuses and 22 fetuses at risk of anemia because of Rh incompatibility. The technique successfully identified all the fetuses who developed anemia before they developed complications. The false-positive rate was 9%.

Evaluation, Fetus, Medical examination, Doppler ultrasonography

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A high-sensitivity alternative to "routine" genetic amniocentesis: multiple urinary analytes, nuchal thickness, and age

Article Abstract:

A non-invasive prenatal test for Down syndrome may be beneficial in women who do not want amniocentesis. During amniocentesis, a needle is inserted into the woman's abdomen and uterus to withdraw amniotic fluid for examination. Researchers measured estrogen and the beta-core fragment of human chorionic gonadotropin in urine samples from 457 pregnant women. Ultrasound was used to measure the thickness of the fetus's neck. These three measurements combined with the woman's age were able to detect all 13 of the fetuses with Down syndrome with a false-positive rate of only 5%.

Innovations, Down syndrome, Prenatal diagnosis

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