A prognostic score for advanced Hodgkin's disease

Article Abstract:

Some physiological factors may predict which patients with Hodgkin's disease may have a poor prognosis. Researchers analyzed 19 potential prognostic factors in 5,141 patients treated for Hodgkin's disease. Seven factors seemed to be independently associated with progression of disease. They included blood albumin levels, hemoglobin levels, sex, age, disease stage, and white blood cell count. Those with no adverse factors were least likely to experience disease progression and those with five or more were most likely to experience disease progression.

Prognosis

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A biologic definition of Burkitt's lymphoma from transcriptional and genomic profiling

Article Abstract:

A study aims to establish a molecular definition of Burkitt's lymphoma and to search for other clinically relevant subgroups of diffuse large-B-cell lymphoma, using transcriptional and genomic profiling. Results show that in mature aggressive B-cell lymphomas without a gene signature for Burkitt's lymphoma, chromosomal breakpoints at the myc locus were associated with an adverse clinical outcome.

Science & research, Research, Genetic aspects, Genetic transcription, Transcription (Genetics), Burkitt's lymphoma, Burkitt lymphoma, Disease/Disorder overview

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Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin's disease

Article Abstract:

Greater than normal doses of a chemotherapy regimen called BEACOPP may be more effective than a regimen called COPP-ABVD for treating patients with advanced Hodgkin's disease. This was the conclusion of a study of 1,195 patients. BEACOPP contains bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone.

Drug therapy

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