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A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1

Article Abstract:

It may not be possible to shorten the length of treatment for HIV infection in pregnant women to save money, according to a study of 1,437 HIV infected pregnant women. Shorter treatment periods led to a higher rate of viral transmission than longer treatment periods.

Author: McIntosh, Kenneth, Essex, Max, Lallemant, Marc, Jourdain, Gonzague, Le Coeur, Sophie, Kim, Soyeon, Koetsawang, Suporn, Comeau, Anne Marie, Phoolcharoen, Wiput, Vithayasai, Vicharn
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
HIV infections, Pregnancy, Zidovudine, HIV infection in pregnancy

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Single-dose perinatal nevirapine plus standard zidovudine to prevent mother-to-child transmission of HIV-1 in Thailand

Article Abstract:

Three different groups of Thai women were given a single dose of nevirapine, nevirapine and placebo and only placebo. It was seen that a single dose of nevirapine to the mother and/or a single dose to the infant added to oral zidovudine prophylaxis is highly effective in reducing the transmission of the human immunodeficiency virus (HIV) from mother to child.

Author: McIntosh, Kenneth, Jourdain, Gonzague, Le Coeur, Sophie, Koetsawang, Suporn, Kanshana, Siripon, Lallement, Marc, Ngo-Giang-Huong, Nicole, Thaineua, Vallop, Mary, Jean Yves
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Thailand, Zidovudine (Medication)

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Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy

Article Abstract:

Intrapartum nevirapine or placebo was given to 1844 Thai women who had received zidovudine in the third trimester of pregnancy. The results show that both antiretroviral prophylaxis and antiretroviral therapy are beneficial against mother-to-child transmission of human immunodeficiency virus (HIV).

Author: Lallemant, Marc, Jourdain, Gonzague, Le Coeur, Sophie, Kantipong, Pacharee, Leechanachai, Pranee, Ariyadej, Surabhon, Leenasirimakul, Prattana, Hammer, Scott, Ngo-Giang-Huong Nicole, Bowownwatanuwong, Chureeratana
Publisher: Massachusetts Medical Society
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
Science & research, Research, Antiviral agents, Antiretroviral agents

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Subjects list: Drug therapy, Dosage and administration, Prevention, HIV (Viruses), HIV, Communicable diseases, Disease transmission, Nevirapine
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