ACE inhibition in acute myocardial infarction

Article Abstract:

Angiotensin-converting-enzyme (ACE) inhibitors may be useful additions to the treatment of heart attack patients in the early stages of their recovery. An individual approach may be useful in prescribing ACE inhibitors to patients who seem to have ventricular dysfunction even though the status of their heart function is not yet known. ACE inhibitors are thought to encourage ventricular remodeling after a heart attack. A study of the ACE inhibitor, zofenopril, found that administration of the drug for six weeks promoted short-term and long-term improvements in outcome. Zofenopril treatment was most effective when begun within 24 hours after heart attack. The drug may cause low blood pressure, so its use should be monitored. Doctors should become familiar with dosages and titration of ACE inhibitors. Trials in progress are studying whether patients with coronary artery disease or normal left ventricular function may benefit from long-term therapy with ACE inhibitors.

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The effect of the angiotensin-converting-enzyme inhibitor zofenopril on mortality and morbidity after anterior myocardial infarction

Article Abstract:

Zofenopril may improve short-term and long-term outcomes when given to patients within 24 hours after a heart attack and continued for six weeks. A study of 1,556 heart attack patients with severe anterior myocardial infarction comparing zofenopril to placebo found that the occurrence of death or severe heart failure within six weeks after the initial event was much lower among the patients treated with zofenopril. Six weeks of treatment with zofenopril improved long-term survival as well. Zofenopril is an angiotensin-converting-enzyme (ACE) inhibitor, a drug which is thought to encourage ventricular remodeling. Patients with severe anterior myocardial infarctions who experience left ventricular dysfunction may have worse outcomes than those whose ventricular function is normal. Early administration of ACE inhibitors in patients with a high risk of heart attack may be advisable.

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Left ventricular hypertrophy in hypertension

Article Abstract:

A 1999 report from the Framingham study illustrates the importance of treating hypertension. The researchers found that the use of antihypertensive drugs had reduced the number of patients with left ventricular hypertrophy. This is the medical term for an enlarged heart. It also decreased the number of patients who had high blood pressure. The lowering of blood pressure is probably more important than the reductions in the size of the heart.

Health aspects, Hypertension, Physiological aspects, Heart enlargement, Heart hypertrophy

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