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AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis

Article Abstract:

A study of three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection is presented. The genetic data and previous studies support the concept that the dynamics by which distinct HLA allotypes render protection against a given infectious pathogen may differ from one another depending on the nature of the antigenic epitopes recognized by these allotypes.

Author: Carrington, Mary, Vlahov, David, Goedert, James J., Buchbinder, Susan, Hoots, Keith, Xiaojiang Gao, Bashirova, Arman, Iversen, Astrid K.N., Phair, John; Altfeld, Marcus, O'Brien Stephen J.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
Development and progression, AIDS (Disease)

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HIV evolution: CTL escape mutation and reversion after transmission

Article Abstract:

Intrapatient accumulation of escape mutations, whether translates into HIV evolution at the population level has not been evaluated. A study was conducted over 300 patients focusing on human leukocyte antigen (HLA) alleles HLA-B57 and HLA-B5801, which are associated with long-term HIV control, and their findings are discussed in detail.

Author: Leslie, A.J., Pfafferott, K.J., Chetty, P., Draenert, R., Addo, M.M.
Publisher: Nature America, Inc.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004

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Phenotypic expressions of CCR5-delta32/delta32 homozygosity

Article Abstract:

People with two copies of the CCR5-delta32 gene mutation have no serious health problems. This means that blocking the CCR5 receptor that HIV uses to infect cells will have no serious adverse effects on HIV patients.

Author: Carrington, Mary, Goedert, James J., O'Brien, Stephen J., Eyster, M. Elaine, O'Brien, Thomas R., Kessler, Craig M., Aledort, Louis M., Cohen, Alan R., Dean, Michael, Konkle, Barbara, Luban, Naomi, Nguyen, Giang T., Beeler, Judith A., Blatt, Philip M., DiMichele, Donna, Leissinger, Cindy
Publisher: Lippincott Williams & Wilkins, WK Health
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
Health aspects, Cell receptors

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Subjects list: Research, United States, HIV infection, HIV infections, HLA histocompatibility antigens, HLA antigens, Histocompatibility antigens
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