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APOE polymorphisms and late-onset Alzheimer disease: the importance of ethnicity

Article Abstract:

More research is needed to determine what factors cause a higher risk of Alzheimer's disease in African Americans. A 1998 study found that the apolipoprotein E (APOE) epsilon4 gene increased the risk of Alzheimer's disease in whites but not in African Americans or Hispanic Americans. In fact, among those without the gene, the risk of Alzheimer's disease was four times greater in African Americans than in whites. This makes race as big a risk factor as the APOE epsilon4 gene, but the reasons for this are not clear.

Author: Martin, George M., Kukull, Walter A.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
Editorial, African Americans, Diseases, Alzheimer's disease

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Association Between Apolipoprotein E [epsilon]4 and Sleep-Disordered Breathing in Adults

Article Abstract:

The apolipoprotein E [epsilon]4 gene appears to increase a person's risk of sleep apnea syndrome. People with this syndrome stop breathing temporarily at various times throughout the night. This gene has also been linked to Alzheimer's disease and cardiovascular disease.

Author: Peppard, Paul E., Young, Terry, Mignot, Emmanuel, Kadotani, Hiroshi, Kadotani, Tomiko, Finn, Laurel, Colrain, Ian M., Murphy Jr., Greer M.
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001

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Risk factors for obstructive sleep apnea in adults

Article Abstract:

Obstructive Sleep Apnea (OSA) is a sleep disorder, which results in episodes of apnea and hypopnea. OSA is also associated with diabetes, hypertension, coronary artery diseases, myocardial infarction, congestive heart failure, and stroke.

Author: Peppard, Paul E., Young, Terry, Skatrud, James
Publisher: American Medical Association
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2004
United States, Demographic aspects, Sleep disorders

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Subjects list: Health aspects, Risk factors, Genetic aspects, Apolipoproteins, Genetic polymorphisms, Sleep apnea syndromes, Sleep apnea
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