Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy

Article Abstract:

Research presented concerns the biological pathways that link cytoskeletal mutations with genetically-based varieties of cardiomyopathy, focusing on the role of alpha-actinin-associated LIM protein (ALP) in the embryonic growth of the right ventricular heart chamber. Findings suggest that inhibition of the gene encoding Alp (in mice) is linked with RV chamber dysfunction and dilation.

Statistical Data Included, Growth, Genetic disorders, Cardiomyopathy, Myocardial diseases, Cytoskeletal proteins, Heart ventricle, Right, Right heart ventricle

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Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

Article Abstract:

Analysis suggests that the suppressor of cytokine signalling-3 (Socs3) is a negative-feedback regulator of leptin signaling involved in leptin resistance. The negative regulatory role of Socs3 in leptin signaling is demonstrated and thereby it is suggested that suppression of Socs3 in the brain is a potential therapy for leptin-resistance in obesity.

Leptin, Cytokines, Cytokine receptors

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Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance

Article Abstract:

This article shows how the deletion of the gene encoding cap protects against high-fat diet-induced insulin resistance in mice. The results show that insulin-sensitive phenotype can be transferred to wild-type mice by transplantation of Sorbs1-null bone marrow.

Health aspects, Methods, Bone marrow, Bone marrow transplantation, Insulin resistance, Genetic code, Ketogenic diet, High fat diet

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