Alterations in fetal and placental deoxyribonucleic acid synthesis rates after chronic fetal placental embolism

Article Abstract:

Measures of DNA synthesis in various muscles may detect abnormally slow growth in fetuses before the decreased growth is identified through weight measurements. A decreased rate of DNA synthesis, especially in the heart muscles, may be the fetus's way of compensating for a lack of oxygen coming from the mother through the placenta. Researchers studied the process of fetal growth retardation by inducing a state of oxygen deprivation in four of nine lamb fetuses; the other five were controls. After 10 days, the weight of fetal organs, the placenta, and the fetus did not vary significantly from controls. However, the rate of DNA synthesis was reduced, signifying decreased tissue growth. The fetus may adapt to the lack of oxygen by slowing its growth to preserve the functioning of its heart.

Fetus, DNA, Growth, Hypoxia, Anoxia, Fetal development, Placental diseases, Placenta diseases

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Prediction of umbilical artery base excess by intrapartum fetal oxygen saturation monitoring

Article Abstract:

Oxygen saturation (SpO2) measurements during labor do not appear to be useful in identifying infants at risk of increased blood acid conditions at birth. SpO2 levels of 54 at-risk fetuses during labor were compared with their blood gas and pH levels at birth. Base excess and pH values at birth did not significantly correlate with SpO2 values obtained during the last 30 minutes of monitoring. SpO2 values obtained during labor did, however, correlate with SpO2 values measured at birth.

Diagnosis, Measurement, Oxygen, Oxygen in the body, Acidosis, Fetal anoxia

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